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August 2024, Vol 10, No. 8, Pages 1013-1140

Original Investigation

Perioperative Modified FOLFIRINOX for Resectable Pancreatic Cancer: A Nonrandomized Controlled Trial

Abstract Full Text
open access
JAMA Oncol. 2024;10(8):1027-1035. doi:10.1001/jamaoncol.2024.1575

This nonrandomized controlled trial assesses whether neoadjuvant modified 5-fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFIRINOX) leads to early control of micrometastasis and improves survival.

Home Time Among Older Adults With Acute Myeloid Leukemia Following Chemotherapy

Abstract Full Text
JAMA Oncol. 2024;10(8):1038-1046. doi:10.1001/jamaoncol.2024.1823

This retrospective cohort study quantifies and compares home time for older patients with newly diagnosed acute myeloid leukemia receiving either hypomethylating agents or anthracycline-based chemotherapy.

Survival in Patients With Recurrent Intermediate-Stage Hepatocellular Carcinoma: Sorafenib Plus TACE vs TACE Alone Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. 2024;10(8):1047-1054. doi:10.1001/jamaoncol.2024.1831

This randomized clinical trial evaluates the efficacy and safety of transarterial chemoembolization (TACE) plus sorafenib vs TACE alone for patients with recurrent intermediate-stage hepatocellular carcinoma.

Postrecurrence Treatment in Neoadjuvant or Adjuvant FDA Registration Trials: A Systematic Review

Abstract Full Text
open access
JAMA Oncol. 2024;10(8):1055-1059. doi:10.1001/jamaoncol.2024.1569

This systematic review examines the proportion and quality of postrecurrence treatment among patients in US Food and Drug Administration (FDA) registration trials of anticancer therapy in the neoadjuvant or adjuvant setting.

Performance of Tumor Surveillance for Children With Cancer Predisposition

Abstract Full Text
JAMA Oncol. 2024;10(8):1060-1067. doi:10.1001/jamaoncol.2024.1878

This cohort study evaluates surveillance outcomes across a wide spectrum of cancer predisposition syndromes in children and young adults.

Endometrial Thickness as Diagnostic Triage for Endometrial Cancer Among Black Individuals

Abstract Full Text
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JAMA Oncol. 2024;10(8):1068-1076. doi:10.1001/jamaoncol.2024.1891

This diagnostic study of Black patients assesses the false-negative probability and accuracy of ultrasonography-measured endometrial thickness thresholds as triage for endometrial cancer diagnosis.

Tumor-Infiltrating Lymphocytes in Patients With Stage I Triple-Negative Breast Cancer Untreated With Chemotherapy

Abstract Full Text
JAMA Oncol. 2024;10(8):1077-1086. doi:10.1001/jamaoncol.2024.1917

This cohort study examines the association between the presence of stromal tumor-infiltrating lymphocytes and survival among patients with stage I triple-negative breast cancer (TNBC) for whom chemotherapy may not be beneficial.

Pancreatic Cancer Surveillance and Survival of High-Risk Individuals

Abstract Full Text
open access
JAMA Oncol. 2024;10(8):1087-1096. doi:10.1001/jamaoncol.2024.1930

This cohort study compares survival of high-risk patients with screen-detected pancreatic cancer with a matched cohort from the Surveillance, Epidemiology, and End Results program.

Fluorine-18 Prostate-Specific Membrane Antigen–1007 PET/CT vs Multiparametric MRI for Locoregional Staging of Prostate Cancer

Abstract Full Text
open access
JAMA Oncol. 2024;10(8):1097-1103. doi:10.1001/jamaoncol.2024.3196

This study assesses the accuracy of fluorine-18 prostate-specific membrane antigen–1007 positron emission tomography (PET)/computed tomography (CT) compared to multiparametric magnetic resonance imaging (MRI) in locoregional staging of prostate cancer.

Brief Report

Measurable Residual FLT3 Internal Tandem Duplication Before Allogeneic Transplant for Acute Myeloid Leukemia

Abstract Full Text
JAMA Oncol. 2024;10(8):1104-1110. doi:10.1001/jamaoncol.2024.0985

This cohort study examines the association between pre–allogeneic hematopoietic cell transplant FLT3 internal tandem duplication measurable residual disease level with relapse and death posttransplant in adults with acute myeloid leukemia in first complete remission.

Long-Term Prospective Outcomes of Intensity Modulated Radiotherapy for Locally Advanced Lung Cancer: A Secondary Analysis of a Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. 2024;10(8):1111-1115. doi:10.1001/jamaoncol.2024.1841

This secondary analysis of a phase 3 randomized clinical trial compares survival and safety outcomes of intensity-modulated radiotherapy to 3-dimensional conformal radiotherapy in combined modality treatment of patients with unresectable locally advanced non–small cell lung cancer.

Adjuvant Gemcitabine Plus Cisplatin and Chemoradiation in Patients With Gallbladder Cancer: A Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. 2024;10(8):1116-1120. doi:10.1001/jamaoncol.2024.1944

This randomized clinical trial examines adequate early survival rates of treatment with adjuvant gemcitabine plus cisplatin compared with concurrent chemoradiation with capecitabine in patients with resected stage II and stage III gallbladder cancers.

Research Letter

Geographic Distribution of Clinical Trials for Advanced-Stage Cancer

Abstract Full Text
open access
JAMA Oncol. 2024;10(8):1132-1133. doi:10.1001/jamaoncol.2024.1690

This quality improvement study evaluates the geographic distribution of clinical trials and assesses the distances patients with cancer must travel to access a clinical trial site.

Review

Current Management of Desmoid Tumors: A Review

Abstract Full Text
has active quiz
JAMA Oncol. 2024;10(8):1121-1128. doi:10.1001/jamaoncol.2024.1805

This review describes the process of updating the global evidence-based consensus guideline on management of desmoid tumor.

JAMA Oncology Clinical Challenge

Lymphoma With a Skin Rash

Abstract Full Text
has active quiz
JAMA Oncol. 2024;10(8):1129-1131. doi:10.1001/jamaoncol.2024.1558

A 62-year-old female had a generalized vesiculobullous rash on her face for 4 months. It started over the lips and gradually progressed to involve the oral mucosa and skin of the whole body. What is your diagnosis?

Viewpoint

Radiation With Immunotherapy May Be a Double-Edged Sword—How Can We Learn From Recent Negative Clinical Trials?

Abstract Full Text
JAMA Oncol. 2024;10(8):1019-1020. doi:10.1001/jamaoncol.2024.1527

This Viewpoint explains differences between recent studies using radiotherapy with immunotherapy and possible reasons for their different outcomes.

Assessing the Evidence for Circulating Tumor HPV DNA in Patients With Oropharyngeal Cancer

Abstract Full Text
JAMA Oncol. 2024;10(8):1021-1022. doi:10.1001/jamaoncol.2024.1821

This Viewpoint evaluates the use of tumor tissue–modified human papillomavirus (HPV) DNA in identifying minimal residual disease.

Advancing Precision Equity With Multicancer Detection Liquid Biopsies

Abstract Full Text
JAMA Oncol. 2024;10(8):1023-1024. doi:10.1001/jamaoncol.2024.1860

This Viewpoint discusses the clinical and socioeconomic potential of multicancer detection liquid biopsies.

Invited Commentary

The Sequencing Conundrum in Localized Pancreatic Adenocarcinoma—Progress or Passive Acceptance?

Abstract Full Text
JAMA Oncol. 2024;10(8):1036-1037. doi:10.1001/jamaoncol.2024.0870
Cancer Care Chronicles

Caregiver Burden—Within and Without

Abstract Full Text
JAMA Oncol. 2024;10(8):1025-1026. doi:10.1001/jamaoncol.2024.2482

This essay describes the experience of an oncologist in India and palliative care involving grieving families and coconuts.

Poetry and Oncology

Piercing the Fog

Abstract Full Text
JAMA Oncol. 2024;10(8):1140. doi:10.1001/jamaoncol.2024.1865
Comment & Response

Immunotherapy For US Patients With Metastatic Cancer at the End of Life

Abstract Full Text
JAMA Oncol. 2024;10(8):1133-1134. doi:10.1001/jamaoncol.2024.1563

Immunotherapy For US Patients With Metastatic Cancer at the End of Life—Reply

Abstract Full Text
JAMA Oncol. 2024;10(8):1134. doi:10.1001/jamaoncol.2024.1566

Valid Analysis of Brain-Specific Progression-Free Survival

Abstract Full Text
JAMA Oncol. 2024;10(8):1134-1135. doi:10.1001/jamaoncol.2024.1693

Valid Analysis of Brain-Specific Progression-Free Survival

Abstract Full Text
JAMA Oncol. 2024;10(8):1135. doi:10.1001/jamaoncol.2024.1696

Valid Analysis of Brain-Specific Progression-Free Survival—Reply

Abstract Full Text
JAMA Oncol. 2024;10(8):1136. doi:10.1001/jamaoncol.2024.1699

Comprehensive Risk Stratification to Guide an Optimal Preventive Strategy for Breast Radiation Dermatitis

Abstract Full Text
JAMA Oncol. 2024;10(8):1136-1137. doi:10.1001/jamaoncol.2024.2206

Comprehensive Risk Stratification to Guide an Optimal Preventive Strategy for Breast Radiation Dermatitis—Reply

Abstract Full Text
JAMA Oncol. 2024;10(8):1137-1138. doi:10.1001/jamaoncol.2024.2209
Correction

Errors in Table

Abstract Full Text
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JAMA Oncol. 2024;10(8):1138. doi:10.1001/jamaoncol.2024.3130

Error in Byline

Abstract Full Text
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JAMA Oncol. 2024;10(8):1138. doi:10.1001/jamaoncol.2024.3182

Error in the Abstract

Abstract Full Text
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JAMA Oncol. 2024;10(8):1138. doi:10.1001/jamaoncol.2024.3526

Change to Open Access

Abstract Full Text
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JAMA Oncol. 2024;10(8):1138. doi:10.1001/jamaoncol.2024.3575
JAMA Oncology Masthead

JAMA Oncology

Abstract Full Text
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JAMA Oncol. 2024;10(8):1013. doi:10.1001/jamaoncol.2023.4656
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