August 20, 2024, Vol 332, No. 7, Pages 517-600

In This Issue of JAMA

Audio Highlights

Abstract Full Text

free access online only has audio

JAMA. 2024;332(7):e2318374. doi:10.1001/jama.2023.18374

Audio: Ivonescimab in Lung Cancer, Preop Skin Antisepsis, Review of Obesity Medications, and more

Original Investigation

Povidone Iodine vs Chlorhexidine Gluconate in Alcohol for Preoperative Skin Antisepsis: A Randomized Clinical Trial

Andreas F. Widmer, MD, MS; Andrew Atkinson, PhD; Stefan P. Kuster, MD; et al.

Abstract Full Text

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JAMA. 2024;332(7):541-549. doi:10.1001/jama.2024.8531

This multicenter, cluster-randomized, noninferiority trial investigates the effectiveness of povidone iodine vs chlorhexidine gluconate in alcohol as preoperative skin antisepsis in preventing surgical site infections in adults undergoing abdominal or cardiac surgery.

Editor's Note
Skin Antisepsis to Prevent Surgical Site Infections: Implications for Global Surgery
Anthony Charles, MD, MPH; Preeti N. Malani, MD, MSJ

JAMA

Tirzepatide for Weight Reduction in Chinese Adults With Obesity: The SURMOUNT-CN Randomized Clinical Trial

Lin Zhao, MD; Zhifeng Cheng, MD; Yibing Lu, MD; et al.

Abstract Full Text

JAMA. 2024;332(7):551-560. doi:10.1001/jama.2024.9217

This randomized clinical trial investigates the safety and efficacy of treatment with once-weekly tirzepatide for weight reduction in Chinese adults with overweight or obesity without diabetes over a 52-week period.

Editorial
Tirzepatide—New Evidence for the Treatment of Obesity From China
Weiping Jia, MD, PhD; Jianzhong Xiao, MD, PhD; Juliana C.N. Chan, MBChB, MD

JAMA
Efficacy of Tirzepatide for Weight Loss in China: Implications for the Global Obesity Epidemic
Frank Qian, MD, MPH; Frank B. Hu, MD, PhD

JAMA

Ivonescimab Plus Chemotherapy in Non–Small Cell Lung Cancer With EGFR Variant: A Randomized Clinical Trial

HARMONi-A Study Investigators

Abstract Full Text

JAMA. 2024;332(7):561-570. doi:10.1001/jama.2024.10613

This randomized clinical trial examines the efficacy of ivonescimab plus chemotherapy vs chemotherapy alone for patients with advanced or metastatic non–small cell lung cancer with the epidermal growth factor receptor (EGFR) variant.

Research Letter

Adolescent Use, Diversion Sources, and Perceived Procurement Difficulty of Prescription Medications

Sean Esteban McCabe, PhD; Emily Pasman, PhD; Tim Wilens, MD; et al.

Abstract Full Text

JAMA. 2024;332(7):587-589. doi:10.1001/jama.2024.12030

This study examines trends in medical use, nonmedical use, diversion sources, and perceived procurement difficulty of prescription medications for nonmedical use among US adolescents.

Website Content and Funding of Officially Recognized Disease Awareness Campaigns

Minna Johansson, MD, PhD; Loai Albarqouni, MD, MSc, PhD; Mary O’Keeffe, PhD; et al.

Abstract Full Text

JAMA. 2024;332(7):589-592. doi:10.1001/jama.2024.12267

This study examines the content, including mention of benefits and harms of testing and treatment, and funding of disease awareness campaign websites recognized by major noncommercial institutions.

Viewpoint

The Supreme Court Decision on Firearm Ownership for People Subject to Restraining Orders

Lawrence O. Gostin, JD; Stephen I. Vladeck, JD

Abstract Full Text

JAMA. 2024;332(7):527-528. doi:10.1001/jama.2024.13915

This Viewpoint explicates the complex reasoning the US Supreme Court has used in rulings on gun control and raises concerns that the recent Rahimi decision poses more questions than it settled on the future of the Second Amendment.

Moving Beyond Statements to Protect Transgender Youth

Melissa Santos, PhD; William T. Zempsky, MD, MPH; Jim Shmerling, DHA

Abstract Full Text

JAMA. 2024;332(7):529-530. doi:10.1001/jama.2024.10196

This Viewpoint explores the politicized nature of gender-affirming care for transgender and nonbinary youth and how children’s hospitals can provide education, resources, and access to families seeking care.

The Evolving Role of Diversity, Equity, and Inclusion Programs in Academic Health Institutions

Yvette Cozier, DSc; Lisa Mellman, MD; Sandro Galea, MD, MPH, DrPH

Abstract Full Text

JAMA. 2024;332(7):531-532. doi:10.1001/jama.2024.9951

This Viewpoint examines the role of diversity, equity, and inclusion programs in academic health institutions and universities and encourages such institutions to reexamine and reengage with the goals of these programs.

The Origins of “Confidential Commercial Information” at the FDA

C. Joseph Ross Daval, JD; Aaron S. Kesselheim, MD, JD, MPH

Abstract Full Text

JAMA. 2024;332(7):533-534. doi:10.1001/jama.2024.9639

This Viewpoint reviews regulations regarding FDA’s handing of confidential commercial information, explains how these regulations serve as a barrier to disclosure of information in the interest of public health, and suggests how information could be carefully shared to improve health outcomes and advance research.

A Piece of My Mind

Don’t Waste Your Cancer

Monica J. Lim, MD

Abstract Full Text

JAMA. 2024;332(7):535. doi:10.1001/jama.2024.10920

In this narrative medicine essay, a pediatric neurology resident who survived childhood cancer reflects on her experience and later how it affected her mother and by extension how life-threatening diagnoses of children impact their parents, grandparents, and siblings.

Editorial

Tirzepatide—New Evidence for the Treatment of Obesity From China

Weiping Jia, MD, PhD; Jianzhong Xiao, MD, PhD; Juliana C.N. Chan, MBChB, MD

Abstract Full Text

JAMA. 2024;332(7):536-538. doi:10.1001/jama.2024.9104

Editorial
Efficacy of Tirzepatide for Weight Loss in China: Implications for the Global Obesity Epidemic
Frank Qian, MD, MPH; Frank B. Hu, MD, PhD

JAMA

Efficacy of Tirzepatide for Weight Loss in China: Implications for the Global Obesity Epidemic

Frank Qian, MD, MPH; Frank B. Hu, MD, PhD

Abstract Full Text

JAMA. 2024;332(7):538-540. doi:10.1001/jama.2024.7928

Editorial
Tirzepatide—New Evidence for the Treatment of Obesity From China
Weiping Jia, MD, PhD; Jianzhong Xiao, MD, PhD; Juliana C.N. Chan, MBChB, MD

JAMA

Review

Medications for Obesity: A Review

Kimberly A. Gudzune, MD, MPH; Robert F. Kushner, MD, MS

Abstract Full Text

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JAMA. 2024;332(7):571-584. doi:10.1001/jama.2024.10816

This review examines the safety and efficacy of various antiobesity medications in conjunction with lifestyle modification according to their mechanism of action, including intragastrointestinal, centrally acting, and nutrient-stimulated hormone-based medications.

Audio: Obesity Medications

JAMA Clinical Guidelines Synopsis

Management of Patients With Chronic Coronary Disease

Charles A. German, MD, MS; Andrew M. Davis, MD, MPH; Tamar S. Polonsky, MD, MSC

Abstract Full Text

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JAMA. 2024;332(7):585-586. doi:10.1001/jama.2024.9813

This JAMA Clinical Guidelines Synopsis summarizes the 2023 American Heart Association (AHA)/American College of Cardiology (ACC) guideline on management of patients with chronic coronary disease.

Editor's Note

Skin Antisepsis to Prevent Surgical Site Infections: Implications for Global Surgery

Anthony Charles, MD, MPH; Preeti N. Malani, MD, MSJ

Abstract Full Text

JAMA. 2024;332(7):550. doi:10.1001/jama.2024.9622

Medical News & Perspectives

New Data on GLP-1s, Diabetic Retinopathy, and CGMs—Highlights From the ADA’s Scientific Sessions

Jennifer Abbasi

Abstract Full Text

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JAMA. 2024;332(7):519-521. doi:10.1001/jama.2024.11510

This Medical News article is an interview with Robert Gabbay, MD, PhD, the American Diabetes Association’s chief scientific and medical officer.

Audio: Clinical Highlights From the American Diabetes Association’s Scientific Sessions

Quick Uptakes

COVID-19 May Protect Against the Common Cold—Here’s Why Knowing That Could Lead to Better Vaccines

Lori Youmshajekian, MA

Abstract Full Text

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JAMA. 2024;332(7):522-523. doi:10.1001/jama.2024.13382

This Medical News article discusses new research on immune system cross-reactivity to different coronaviruses and implications for pan-coronavirus vaccines.

Audio: July 2024 Medical News Summary

Medical News in Brief

CDC Revises RSV Vaccination Recommendation for Older Adults in US

Emily Harris

Abstract Full Text

JAMA. 2024;332(7):524. doi:10.1001/jama.2024.13385

FDA Green-Lights Second Alzheimer Drug, Donanemab

Emily Harris

Abstract Full Text

JAMA. 2024;332(7):524. doi:10.1001/jama.2024.13386

Study: Polypharmacy Nearly Doubled in 20 Years Among Older Adults in US

Emily Harris

Abstract Full Text

JAMA. 2024;332(7):524. doi:10.1001/jama.2024.13387

FDA Proposes Guidance for Increasing Diversity in Clinical Trials

Emily Harris

Abstract Full Text

JAMA. 2024;332(7):524. doi:10.1001/jama.2024.13388

COVID-19 Vaccination in Early Pregnancy Not Linked to Birth Defects

Emily Harris

Abstract Full Text

JAMA. 2024;332(7):524-525. doi:10.1001/jama.2024.13389

First-Line Antidepressants Tied to Minor Differences in Weight Gain

Emily Harris

Abstract Full Text

JAMA. 2024;332(7):525. doi:10.1001/jama.2024.13390

WHO: Global Deaths From Alcohol Remain High

Emily Harris

Abstract Full Text

JAMA. 2024;332(7):525. doi:10.1001/jama.2024.13391

HHS Invests in Training Clinicians, Caregivers to Support Older Adults

Emily Harris

Abstract Full Text

JAMA. 2024;332(7):525. doi:10.1001/jama.2024.13392

Monetary Incentives May Improve Chances of Quitting Smoking

Emily Harris

Abstract Full Text

JAMA. 2024;332(7):525. doi:10.1001/jama.2024.13393

Poetry and Medicine

Safe in Bed

Mary Meriam, MFA

Abstract Full Text

JAMA. 2024;332(7):596. doi:10.1001/jama.2024.9536

JAMA Revisited

The Progress of Surgery

Abstract Full Text

JAMA. 2024;332(7):597. doi:10.1001/jama.2023.18375

JAMA Patient Page

Obesity in Adults

Laura A. Campbell, MD; Rachana Kombathula, MD; Christopher D. Jackson, MD

Abstract Full Text

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JAMA. 2024;332(7):600. doi:10.1001/jama.2024.5126

This JAMA Patient Page defines obesity in adults and describes the health effects of obesity, the treatment options available, and the health benefits of weight loss.

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