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August 19, 2024
Viewpoint

Expanding the Prion Paradigm to Include Alzheimer and Parkinson Diseases

Abstract Full Text
JAMA Neurol. Published online August 19, 2024. doi:10.1001/jamaneurol.2024.2464

This Viewpoint describes the evidence for iatrogenic disease based on amyloid-β prions and the possibility that Alzheimer disease has an iatrogenic form wherein amyloid β and tau behave as prions that transmit the disease.

Editorial

JAMA Neurology Editorial Fellowship—Call for Applicants

Abstract Full Text
JAMA Neurol. Published online August 19, 2024. doi:10.1001/jamaneurol.2024.2554
Original Investigation

Localized Nicardipine Release Implants for Prevention of Vasospasm After Aneurysmal Subarachnoid Hemorrhage: A Randomized Clinical Trial

Abstract Full Text
open access has audio
JAMA Neurol. Published online August 19, 2024. doi:10.1001/jamaneurol.2024.2564

This randomized clinical trial investigated the safety and efficacy of nicardipine release implants for preventing proximal angiographic vasospasm after aneurysmal subarachnoid hemorrhage.

Lecanemab and Vascular-Amyloid Deposition in Brains of People With Down Syndrome

Abstract Full Text
JAMA Neurol. Published online August 19, 2024. doi:10.1001/jamaneurol.2024.2579

This study investigates the binding properties of lecanemab in the brains of people with Down syndrome, in anticipation of their inclusion in clinical trials or access to antiamyloid immunotherapies.

Comment & Response

Sex Differences in Case-Fatality Rates of Stroke

Abstract Full Text
JAMA Neurol. Published online August 19, 2024. doi:10.1001/jamaneurol.2024.2596

Sex Differences in Case-Fatality Rates of Stroke—Reply

Abstract Full Text
JAMA Neurol. Published online August 19, 2024. doi:10.1001/jamaneurol.2024.2599
August 12, 2024
Viewpoint

It Is Time for Medicare to Cover Driving Safety Assessments

Abstract Full Text
JAMA Neurol. Published online August 12, 2024. doi:10.1001/jamaneurol.2024.2461

This Viewpoint advocates for Medicare coverage of driving assessments for older individuals.

Original Investigation

Apixaban vs Aspirin in Patients With Cancer and Cryptogenic Stroke: A Post Hoc Analysis of the ARCADIA Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. Published online August 12, 2024. doi:10.1001/jamaneurol.2024.2404

This secondary analysis of the Atrial Cardiopathy and Antithrombotic Drugs in Prevention After Cryptogenic Stroke (ARCADIA) randomized clinical trial compares apixaban vs aspirin for the prevention of adverse clinical outcomes in patients with history of cancer and cryptogenic stroke.

Review

Endovascular Stroke Thrombectomy for Patients With Large Ischemic Core: A Review

Abstract Full Text
has active quiz
JAMA Neurol. Published online August 12, 2024. doi:10.1001/jamaneurol.2024.2500

This narrative review discusses the results of 6 recently published trials on the efficacy and safety of endovascular thrombectomy as treatment for patients with ischemic stroke, anterior-circulation large vessel occlusions, and large areas of ischemic change and highlights areas of persistent uncertainty in the use of this treatment.

Images in Neurology

Parkinsonism Following Chimeric Antigen Receptor T Cell Therapy

Abstract Full Text
has active quiz
JAMA Neurol. Published online August 12, 2024. doi:10.1001/jamaneurol.2024.2506

This case report describes a 67-year-old woman who had received adoptive immunotherapy with chimeric antigen receptor T cells for multiple myeloma and was experiencing parkinsonism-like symptoms.

August 5, 2024
Viewpoint

Limitations of the α-Synuclein Seed Amplification Assay in Clinical Practice: Understanding the Pathological Diversity of Parkinson Syndrome

Abstract Full Text
JAMA Neurol. Published online August 5, 2024. doi:10.1001/jamaneurol.2024.2381

This Viewpoint cautions against premature adoption of the α-synuclein seed amplification assay as a biomarker test for Parkinson disease in general neurology practice.

Original Investigation

Risk of Perinatal and Maternal Morbidity and Mortality Among Pregnant Women With Epilepsy

Abstract Full Text
open access
JAMA Neurol. Published online August 5, 2024. doi:10.1001/jamaneurol.2024.2375

This study attempts to determine the risk of severe maternal and perinatal morbidity and mortality among women with epilepsy.

Combined Physiotherapy and Cognitive Behavioral Therapy for Functional Movement Disorders: A Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. Published online August 5, 2024. doi:10.1001/jamaneurol.2024.2393

This randomized clinical trial investigates the efficacy of combination physiotherapy and cognitive behavioral therapy for individuals with functional movement disorders.

Research Letter

Pain Phenotypes and Pain Multimorbidity Among Medicare Beneficiaries With Cerebral Palsy

Abstract Full Text
open access
JAMA Neurol. Published online August 5, 2024. doi:10.1001/jamaneurol.2024.2443

This cohort study assesses the association of pain phenotypes and pain multimorbidity with cerebral palsy subtypes among Medicare beneficiaries.

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